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THE CONSERVATORY OF MEDICAL ARTS AND SCIENCES
XVII
THE SEARCHLIGHT MESSENGER
THE SEARCHLIGHT MESSENGER
Blog
The Next Generation Test Tube Babies
| Posted on July 14, 2013 at 9:53 PM |
Most of my students have heard my lectures on “Our Current
Definitions of Good Health”, and what changed in the twentieth century to
double Man’s “Life Expectancy”.
Realize that Life Expectancy is not the same number we use for “The LifeSpan of Man”, but the two measurements continue to move together in
concert. In 2011, the scientific community changed “The Life Span of
Man” from one hundred years (where it has always been) to one hundred thirty
years. Keep in mind that what we call Life Expectancy, changed from forty-three
years in 1903, to eighty six years in 2003. Both of these figures are huge
leaps. Prior to the Age of Enlightenment (The Sixteenth Century), most people
didn’t live much longer than thirty. So the questions are: What happened that
doubled our Life Expectancy in one hundred short years, and what happened by
2010, measuring boldly, that our Life Span had reached an additional thirty
years, and moreover, is expected to increase again in 2017, to one hundred
seventy years. When the scientific community makes this statement, they are
also telling us that it is not difficult to reach the age of one hundred ten
right now, given the access to medical advancements already in place.  One hundred years ago, the top killers of Man were Trauma,
Tuberculosis, Small Pox, Diphtheria, and Influenza. The top killers now? They
are all diseases of aging. Heart Attacks, Strokes, Cancer, Diabetes, Obesity.
And trauma still plays a huge role in dragging that “expectancy” number down. I know what you’re thinking. During the Twentieth Century,
two world wars taught doctors how to triage and develop better and better
trauma surgery technology as well as skill. Antibiotics created a paradigm
shift in the treatment of disease. Don’t forget kidney dialysis, cancer chemotherapy,
and our pharmacologic weaponry, in addition to open heart surgery and
transplantation.
These were responsible only for a small blip. The real
winner was Prevention. Even with all of that “medical stuff”, what really
doubled our Life Expectancy in the twentieth Century, was Vaccination. Just ask any “Baby Boomer” physician in The United
States if he has ever seen a case of Diphtheria, a disease with a 90% mortality
rate. What is now pushing us forward, are other prevention
techniques. As our technology increases, we see the stem cell, artificial
insemination, and nanotechnology taking us in directions only dreamed about ten
years ago. The two Nobel Prizes awarded for Telomer Research speak for
themselves with regard to our ability to manipulate the aging process of genes
we call “programmed apoptosis” and slow down aging exponentially, in addition
to our ability to understand cancer cells and why they grow unchecked. Yeah, we
can turn that switch on, to halt aging, or turn the switch off, to kill cancer. At the forefront of all of this is, Nanotechnology and our
knowledge of The Genome. Our complete map of Human DNA is allowing us to remove
dangerous congenital diseases, before our babies are even born.
The article below is about an announcement from medical
scientists, less than one week ago. Read on: From "The Scientist"; July, 2013 The Next Generation Test Tube Baby Abnormalities
in the DNA of embryos account for the two-thirds failure rate of in
vitrofertilization (IVF)—a procedure where eggs are fertilized by sperm
in a dish, then later implanted in the uterus. Genetic tests exist to
screen for embryos with chromosomal or genetic defects prior to
implantation, but the tests are expensive and have drawbacks.
Researchers at the University of Oxford have developed a relatively
inexpensive next-generation sequencing technique that overcomes the
limitations of previous tests, and has already been used in the IVF
procedure that resulted in the birth of a baby boy in May. The research
was reported Monday (July 8) at the annual meeting of the European Society of Human Reproduction and Embryology in London.
The new sequencing technique allows researchers to examine each embryo
created with IVF for abnormal numbers of chromosomes, individual gene
mutations, and mitochondrial genome mutations. The analysis can be
completed in only 16 hours, meaning embryos do not need to be frozen
awaiting test outcomes. The researchers claim the new test will be
cheaper than current screening procedures, which can cost thousands of
dollars.
“Next-generation sequencing improves our ability to detect these
abnormalities and helps us identify the embryos with the best chances of
producing a viable pregnancy,” said Dagan Wells, a molecular geneticist at the NIHR Biomedical Research Centre at the University of Oxford, in a statement. “Potentially, this should lead to improved IVF success rates and a lower risk of miscarriage.”
The new screen helped Marybeth Scheidts, 36, and her husband David
Levy, 41, of Philadelphia, achieve a successful pregnancy, resulting in
the birth of their son, Connor Levy, in May. The couple had tried to
conceive naturally for 4 years and had also tried artificial
insemination.
“Anything that is so significantly going to impact pregnancy rates is
going to become standard,” Michael Glassner, the fertility doctor at the
Main Line Fertility Clinic where the screening procedure took place,
told BBC News. He added that he thinks the test will become standard within 5 years. “Our next step is a randomized clinical trial to reveal the true
efficacy of this approach—and this will begin later this year”. |
Categories: Science Update
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396 Comments
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They are all diseases of aging. Heart Attacks, Strokes, Cancer, Diabetes, Obesity. And trauma still plays a huge role in dragging that “expectancy” number down.
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